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Mathematical modeling is critical to our understanding of how infectious diseases spread at the individual and population levels. This book gives readers the necessary skills to correctly formulate and analyze mathematical models in infectious disease epidemiology, and is the first treatment of the subject to integrate deterministic and stochastic models and methods. Mathematical Tools for Understanding Infectious Disease Dynamicsfully explains how to translate biological assumptions into mathematics to construct useful and consistent models, and how to use the biological interpretation and mathematical reasoning to analyze these models. It shows how to relate models to data through statistical inference, and how to gain important insights into infectious disease dynamics by translating mathematical results back to biology. This comprehensive and accessible book also features numerous detailed exercises throughout; full elaborations to all exercises are provided. Covers the latest research in mathematical modeling of infectious disease epidemiologyIntegrates deterministic and stochastic approachesTeaches skills in model construction, analysis, inference, and interpretationFeatures numerous exercises and their detailed elaborationsMotivated by real-world applications throughout

Optics--a field of physics focusing on the study of light--is also central to many areas of biology, including vision, ecology, botany, animal behavior, neurobiology, and molecular biology. The Optics of Life introduces the fundamentals of optics to biologists and nonphysicists, giving them the tools they need to successfully incorporate optical measurements and principles into their research. Sönke Johnsen starts with the basics, describing the properties of light and the units and geometry of measurement. He then explores how light is created and propagates and how it interacts with matter, covering topics such as absorption, scattering, fluorescence, and polarization. Johnsen also provides a tutorial on how to measure light as well as an informative discussion of quantum mechanics.

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that help in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in the design of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug design Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system Computational Immunology: Applications focuses on different mathematical models, statistical　tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including　 Next generation sequencing (NGS) and computational immunology Computational modelling and biology of diseases Drug designing　 Computation and identification of biomarkers Application in organ transplantation Application in disease detection and therapy Computational methods and applications in understanding of the invertebrate immune system S Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

Intellectually rich, intensely personal, and beautifully written, Tracks and Shadows is both an absorbing autobiography of a celebrated field biologist and a celebration of beauty in nature. Harry W. Greene, award-winning author of Snakes: The Evolution of Mystery in Nature, delves into the poetry of field biology, showing how nature eases our existential quandaries. More than a memoir, the book is about the wonder of snakes, the beauty of studying and understanding natural history, and the importance of sharing the love of nature with humanity. Greene begins with his youthful curiosity about the natural world and moves to his stints as a mortician's assistant, ambulance driver, and army medic. In detailing his academic career, he describes how his work led him to believe that nature’s most profound lessons lurk in hard-won details. He discusses the nuts and bolts of field research and teaching, contrasts the emotional impact of hot dry habitats with hot wet ones, imparts the basics of snake biology, and introduces the great explorers Charles Darwin and Alfred Russel Wallace. He reflects on friendship and happiness, tackles notions like anthropomorphism and wilderness, and argues that organisms remain the core of biology, science plays key roles in conservation, and natural history offers an enlightened form of contentment.

It is essential for modern students of molecular behavior to understand the physics at the heart of modern molecular science, but traditional presentations of this material are often difficult to penetrate. This volume brings down to earth some of the most intimidating but important theories of molecular biophysics. Students build understanding by focusing on topics such as probability theory, low-dimensional models, and the simplest molecular systems. The book's accessible development of equilibrium and dynamical statistical physics makes this a valuable text for students with limited physics and chemistry backgrounds.

Understanding Mammalian Locomotion will formally introduce the emerging perspective of collision dynamics in mammalian terrestrial locomotion and explain how it influences the interpretation of form and functional capabilities. The objective is to bring the reader interested in the function and mechanics of mammalian terrestrial locomotion to a sophisticated conceptual understanding of the relevant mechanics and the current debate ongoing in the field.

The immune system is highly complex system with large number of macromolecules, signaling pathways, protein-protein interactions, and gene expressions. Studies from genomics, transcriptomics, metabolomics are generating huge high throughput data that needs to be analyzed for understanding the Immune system in Health and Disease. Computational approaches arehelping in understanding the study of complex biology of immunology and thereby enabling design of therapeutic strategies in diseases like infectious diseases, immunodeficiency, allergic, hypersensitive, autoimmune disorders and diseases like Cancer, HIV etc. Computational Immunology: Basics highlights the basics of the immune system and function in health and disease. This book offers comprehensive coverage of the most essential topics, including Overview of Immunology and computational Immunology Immune organs and cells, antigen, antibody, B, cell, T cell Antigen Processing and presentation Diseases due to abnormalities of the immune system Cancer Biology Shyamasree Ghosh (MSc, PhD, PGDHE, PGDBI), is currently working in the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, DAE, Govt of India, graduated from the prestigious Presidency College Kolkata in 1998. She was awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

The research paper \"Extinction Risk from Climate Change\" published in the journal Nature in January 2004 created front-page headlines around the world. The notion that climate change could drive more than a million species to extinction captured both the popular imagination and the attention of policy- makers, and provoked an unprecedented round of scientific critique. Saving a Million Species reconsiders the central question of that paper: How many species may perish as a result of climate change and associated threats? Leaders from a range of disciplines synthesize the literature, refine the original estimates, and elaborate the conservation and policy implications. The book: * examines the initial extinction risk estimates of the original paper, subsequent critiques, and the media and policy impact of this unique study * presents evidence of extinctions from climate change from different time frames in the past * explores extinctions documented in the contemporary record * sets forth new risk estimates for future climate change * considers the conservation and policy implications of the estimates. Saving a Million Species offers a clear explanation of the science behind the headline-grabbing estimates for conservationists, researchers, teachers, students, and policy-makers. It is a critical resource for helping those working to conserve biodiversity take on the rapidly advancing and evolving global stressor of climate change-the most important issue in conservation biology today, and the one for which we are least prepared.

01 02 Examining stem cell biology from a philosophy of science perspective, this book clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. The first chapters discuss what stem cells are, how experiments identify them, and why these two issues cannot be completely separated. The basic concepts, methods and structure of the field are set out, as well as key limitations and challenges. The second part of the book shows how rigorous explanations emerge from stem cell experiments, and compares these to other kinds of scientific explanation. Model organisms, the role of genes, and the significance of collaboration are also discussed. The last part of the book considers relations to systems biology and clinical medicine, arguing that both the mathematical models of the former, and ethical principles of the latter, are necessary for stem cell biology to deliver on its promises. 31 02 An examination of stem cell biology from a philosophy of science perspective with discussions of experiments, evidence, and explanation 13 02 MELINDA BONNIE FAGAN is Assistant Professor of Philosophy at Rice University in Houston, Texas, USA. She has PhDs in Biological Sciences (Stanford University, 1998) and History and Philosophy of Science (Indiana University, Bloomington, 2007) and has published over twenty articles and book chapters on biology and philosophy of science. 19 02 New and current topic of huge importance in science Asks key questions and explains the subject from perspective of philosophy of science Clarifies important concept (stem cells) and associated methods Looks at the empirical evidence and addresses new accounts in philosophy of science like model-building Implications for public understanding of science Implications for science policy 04 02 List of Figures and Tables Acknowledgements Visceral Phenomena PART I Stem Cell Concepts Don't Know What You've Got 'Til It's Gone: Evidence in Stem Cell Experiments A State of Uncertainty: Stemness and the Roles of Theory PART II Mechanistic Explanation: The Joint Account Genes and Development: The Stem Cell Perspective Pluripotent Model Organisms Social Experiments PART III Integrating Stem Cell and Systems Biology Clinical Values Bibliography Index 02 02 This examination of stem cell biology from a philosophy of science perspective clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. Relations to systems biology and clinical medicine are also discussed.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi